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On a more experimental level, an IgG Fc variant engineered for improved binding to both FcRn and activating FcRs by introducing six amino acid substitutions (Y296W/K334N/P352S/A378V/V397M/N434Y) has been shown to be as efficacious as IVIg in mouse models of arthritis and ITP [403]

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15 : 117132 Smith CD, Gallenstein LG, Layton WJ, Kryscio RJ, Markesbery WR

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